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Śrī Īśopaniṣad
and Lord Kṛṣṇa by His plenary expansions is the dominating Figure on each and every one of them.
No one can predominate over Kṛṣṇa. And anyone trying to predominate over material Nature is called a conditioned soul, being subject to the laws of material Nature, suffering the pangs of repeated birth and death. The Lord comes here to re-establish the principles of religion, and the basic principle is to develop the attitude of surrender toward Him. The Lord teaches this in the last portion of the  Bhagavad-gītā , but foolish men have tactfully misinterpreted this prime teaching, and have misled the people in diverse ways. They have been urged to open hospitals, but are not interested in educating themselves to enter into the spiritual kingdom by devotional service. They have been taught to take interest only in temporary relief work, which can never bring about real happiness for the living entity. They start varieties of public and semi-governmental institutions for tackling the devastating power of Nature. But they don't know how to pacify insurmountable Nature.
Many men are advertised as great scholars of the  Bhagavad-gītā , but they overlook the factual method presented there to pacify material Nature. Powerful Nature can only be pacified by the awakening of God consciousness, as is clearly mentioned in the  Gītā .
Śrī Īśopaniṣad, however, teaches in this  mantra  that one must know both the  sambhūti  and the  vināśa  perfectly, side by side. By knowing the  vināśa  alone—the temporary material manifestation—you cannot save anything: In the course of Nature, there is devastation at every moment. No one can be saved from these devastations by any efforts of hospital-opening. They can be saved only by complete knowledge of the eternal life of bliss and awareness. The whole Vedic scheme is meant to educate men in this art of achieving eternal life. People are often misguided by other, temporarily attractive things based on sense gratification, but that sort of service which thus misleads them is most degraded.